Pyogenic Granuloma - Western SummaryWestern Medicine Summary

Western Medicine

Western Summary

A pyogenic granuloma is a vascular neoplasm that tends to occur in the mouth, face, and hands most often. The occurrence in women is slightly greater than men[1] and childhood occurrence is common. They can appear and grow rapidly and may bleed easily. 

Symptoms

Pyogenic granulomas appear like non-healing wounds that have a soft and fleshy overgrowth to them. They bleed easily and constant drain fluid that makes them uncomfortable. 

Causes

Pyogenic granulomas usually occur spontaneously but can be more likely to occur after trauma, during pregnancy or with certain medications. These lesions have one of the estrogen hormone receptors and estrogen may play a role in their development.[2] This may explain why the condition is more often seen in women than in men, but more studies are needed to understand the role of hormones in the development of pyogenic granulomas. 

Treatments

It is important to check for skin cancer as pyogenic granulomas can look like some skin cancers. 

  • Imiquimod: Imiquimod cream 5% applied topically with or without occlusion has been successful in some cases[3] and might be an option in cases where surgical or laser therapy is not favorable.
  • Surgical excision: A qualified healthcare provider can perform a surgical excision with or without cauterizing the base of the tumor with heat. 
  • Lasers: Different lasers have been used including the pulse dye laser and CO2 laser.[1]

1.    Akamatsu T, Hanai U, Kobayashi M, et al. Pyogenic Granuloma: A Retrospective 10-year Analysis of 82 Cases. Tokai J Exp Clin Med.2015;40(3):110-114; PMID: 26369264.

2.    Fortna RR, Junkins-Hopkins JM. A case of lobular capillary hemangioma (pyogenic granuloma), localized to the subcutaneous tissue, and a review of the literature. Am J Dermatopathol.2007;29(4):408-411; PMID: 17667179.

3.    Musumeci ML, Lacarrubba F, Anfuso R, et al. Two pediatric cases of pyogenic granuloma treated with imiquimod 5% cream: combined clinical and dermatoscopic evaluation and review of the literature. G Ital Dermatol Venereol.2013;148(1):147-152; PMID: 23407084.​