Epidermolysis Bullosa Acquisita - Western SummaryWestern Medicine Summary

Western Medicine

Western Summary

Epidermolysis bullosa acquisita (EBA) is a rare disorder that usually occurs in middle-aged people starting in their 40's and can affect both men and women.


EBA is a rare disorder in which firm blisters appear on areas that are easily injured, such as the back of the hands and feet, knees, elbows and buttocks. Occasionally the inside of the mouth, nose and eyes can be affected. When the blisters are broken, sores and small amounts of bleeding are common. The sores then heal with scarring. 


EBA is an autoimmune skin disease where the immune system starts to attack a part of the skin called collagen 7, which helps to hold the upper (epidermis) and lower (dermis) layers of the skin together. This leads to the formation of blisters. 


The skin needs to be protected from injury to prevent further blister formation. Direct physical force to the skin should be avoided as this can cause blisters easily. Spicy, salty, and rough food should be avoided as they can be uncomfortable and irritating if lesions are present in the mouth.

Several medications that are used for treatment include: 

  • Antinflammatory medications: Systemic and topical steroids can help reduce the inflammation 
  • Other medications that suppress the immune system: mycophenolate mofetil, dapsone, and colchicine
  • Intravenous immunoglobulins may be helpful since the theory is that they may neutralize the body’s own antibodies<