The Three Common Types of Skin Cancer

Sun overexposure increases the risk of skin cancer

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Skin cancer is generally dividied into two main groups: non-melanoma skin cancer and melanoma. Melanoma is less common than NMSC, but the prognosis is far worse. Non-melanoma skin cancer is divided into two subtypes: Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC), and it is estimated that over 5 million new cases develop every year.[1] Of these two types, BCC is more common. 


Risk Factors

Sun exposure has long been known to increase the risk of skin cancer: a term called photocarcinogenesis. A 2016 study showed that mice that consumed a high fat diet were at increased risk of photocarcinogenesis, and that a high fat diet also increased the activity of inflammatory mediators in UVR-exposed skin and tumors.[2] A prospective study of Nordic twins evaluated over time found that there is a genetic component to non-melanoma skin cancers and melanoma.[3]

 

Non-Melanoma Skin Cancer

A report from 2016 in the journal Clinical Medicine (London) states that “exposure to UV radiation initiates approximately 90% of NMSC, causing malignant transformation of keratinocytes and suppression of the inflammatory response.”[4]  

A 2016 study from the journal Oncotarget mentions that chronic ultraviolet radiation (UVR) is associated with the development of SCC by inducing pro-inflammatory molecules,[5] and a 2015 study relates the UVR-induced skin response to a deficiency in an enzyme, called TREX2, that is associated with DNA damage removal and degradation.[6]

Sunburns and sun overexposure are clear risk factors for the development of non-melanoma skin cancers. There is a strong relation between SCC and constant or cumulative UVR exposure, and BCC is related to sunburns and high lifetime solar exposure.[7]

 

Melanoma

For melanoma, it appears that gender is more specific to an increased incidence of development than chronic exposure to UVR.[8] In men, it appears that sunburn risk is associated more with the development of melanoma than it is with BCC or SCC.[9]  The same study found that males with a history of sunburn on the trunk have an increased risk of developing melanoma, but the relationship is not as clear between BCC or SCC.[9] In 2014, the journal Cutis published a study evaluating the risk factors for melanoma. The study found that people with lighter-colored skin types, frequent sunburns during childhood, and higher level of education all had increased risk for developing melanoma.[10] It is possible that the relationship between education and melanoma could be due to the fact that people with higher education may be able to take more vacations in which they have increased sun exposure. Future studies will hopefully evaluate this possible connection. 

It is clear that prolonged exposure to UVR can increase the risk of developing all types of skin cancer, and the risk is higher in certain populations. All people should take preventive measures to avoid skin damage from the sun or artificial ultraviolet light, even if they are low risk. High-quality sunscreen, protective clothing, and shade-seeking behavior are all easy and necessary means of lowering the risk of cancer development.

 

* This Website is for general skin beauty, wellness, and health information only. This Website is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. The information provided on this Website should never be used to disregard, delay, or refuse treatment or advice from a physician or a qualified health provider.

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References

​1.    Rogers HW, Weinstock MA, Feldman SR, et al. Incidence Estimate of Nonmelanoma Skin Cancer (Keratinocyte Carcinomas) in the U.S. Population, 2012. JAMA Dermatol.2015;151(10):1081-1086; PMID: 25928283.

2.    Vaid M, Singh T, Prasad R, et al. Intake of high-fat diet stimulates the risk of ultraviolet radiation-induced skin tumors and malignant progression of papillomas to carcinoma in SKH-1 hairless mice. Toxicol Appl Pharmacol.2014;274(1):147-155; PMID: 24211275.

3.    Mucci LA, Hjelmborg JB, Harris JR, et al. Familial Risk and Heritability of Cancer Among Twins in Nordic Countries. JAMA.2016;315(1):68-76; PMID: 26746459.

4.    Griffin LL, Ali FR, Lear JT. Non-melanoma skin cancer. Clin Med (Lond).2016;16(1):62-65; PMID: 26833519.

5.    Singh A, Willems E, Singh A, et al. Ultraviolet radiation-induced tumor necrosis factor alpha, which is linked to the development of cutaneous SCC, modulates differential epidermal microRNAs expression. Oncotarget.2016;7(14):17945-17956; PMID: 26918454.

6.    Manils J, Gomez D, Salla-Martret M, et al. Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis. Oncotarget.2015;6(26):22375-22396; PMID: 26090614.

7.    Calzavara-Pinton P, Ortel B, Venturini M. Non-melanoma skin cancer, sun exposure and sun protection. G Ital Dermatol Venereol.2015;150(4):369-378; PMID: 26186380.

8.    Gordon D, Gillgren P, Eloranta S, et al. Time trends in incidence of cutaneous melanoma by detailed anatomical location and patterns of ultraviolet radiation exposure: a retrospective population-based study. Melanoma Res.2015;25(4):348-356; PMID: 26050147.

9.    Wu S, Cho E, Li WQ, et al. History of Severe Sunburn and Risk of Skin Cancer Among Women and Men in 2 Prospective Cohort Studies. Am J Epidemiol.2016;10.1093/aje/kwv282PMID: 27045074.

10.    Kulichova D, Danova J, Kunte C, et al. Risk factors for malignant melanoma and preventive methods. Cutis.2014;94(5):241-248; PMID: 25474453.